5) Stem Cell Disorders and Epigenetics
نویسندگان
چکیده
منابع مشابه
Stem cell epigenetics: looking forward.
The integrity of tissues is maintained by adult stem cells during adulthood. However, recent work indicates that tissues often contain more than one population of stem cells that are located at distinct niches and display different behaviors, making the role of stem cells in tissue homeostasis far more complex than previously thought. Generally, each population of stem cells predominantly contr...
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Pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. The two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...
متن کاملEpigenetics and Neural Developmental Disorders
Neural developmental disorders, such as autism, Rett Syndrome, Fragile X syndrome, and Angelman syndrome manifest during early postnatal neural development. Although the genes responsible for some of these disorders have been identified, how the mutations of these genes affect neural development is currently unclear. Emerging evidence suggest that these disorders share common underlying defects...
متن کاملStem cells, cancer, and epigenetics∗
The interest in cancer as an epigenetic, as well as a genetic disease, has markedly accelerated over the past decade. This chapter concentrates on one particularly interesting aspect of this – the growing evidence that one of the most studied epigenetic abnormalities in cancer, abnormal gene silencing associated with gene promoter DNA hypermethylation, is linked to key aspects of chromatin regu...
متن کاملEpigenetics of autism spectrum disorders.
The autism spectrum disorders (ASD) comprise a complex group of behaviorally related disorders that are primarily genetic in origin. Involvement of epigenetic regulatory mechanisms in the pathogenesis of ASD has been suggested by the occurrence of ASD in patients with disorders arising from epigenetic mutations (fragile X syndrome) or that involve key epigenetic regulatory factors (Rett syndrom...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2013
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.102.2279